Faculty Research

Brain function and structure in cognitive aging and neurodegenerative disease
Human psychophysiology: emotion, cognition, memory and amnesia
Neural underpinnings of internally-guided cognition, including how they develop and change across the lifespan and how they become dysfunctional in clinical populations; functional MRI; default mode network
Voluntary and respiratory-related neuromuscular control of upper airway muscles
Peripheral neural control of cardiovascular and renal function in health and disease
Sound processing in the healthy and diseased brain
Neurobiological correlates of age-related declines in spatial cognition
Interactions of cognition and neurology in humans and animals
The Bhattacharya Lab studies the molecular pathways that promote axon degeneration in the context of neuronal injury and neurodegenerative disease, using both Drosophila and mouse models.
Systems biology of aging transitions leading to risk of age-related neurodegenerative diseases, sex differences in bioenergetic aging of female and male brain, regenerative therapeutics for neurodegenerative diseases.
Neural circuits of animal behaviors, with a focus on understanding how the neural circuits regulate feeding and emotional behaviors, using optogenetics, pharmacogenetics, electrophysiology, molecular, and behavior analysis tools
Improving optocapacitance as a technique to photostimulate genetically unmodified neurons, by changing their membrane capacitance, in vivo and in vitro
Developing image-guided transcranial magnetic stimulation (TMS) approaches to improve cognitive functions and identifying TMS-derived and imaging-based biomarkers for diagnosis and prediction of therapeutic outcomes in individuals with neurodegenerative d
Understanding how the activities of ensembles of neurons drive our capacity to decide, remember, and navigate
The delivery of neuropharmaceuticals across the Blood Brain Barrier
The emergence of complexity and increased efficiency through collective behavior; effect of scaling in complex systems; the role of learning and individual variability for collective success.
The role of the immune system in chronic neurodegeneration after stroke and brain injury
How inhibitory inputs influence neuronal signaling and sensory signal processing in the retina
Work focuses on the neural basis of human memory, with a particular interest in spatial navigation.
Cellular and rodent models to test novel pharmacological treatments for levodopa-induced dyskinesias, a major side effect of Parkinson’s disease treatment, as well as new neuroprotective gene and drug therapy approaches to Parkinson’s disease
Computational neuroscience, learning and emotional memory, neuromodulation
Identifying circadian factors during middle age that increase risk for later-life cognitive impairment; devloping novel, light-based treatments to stem loss of cognition during aging
Regulation of Breathing
Sensorimotor neurophysiology
The mechanism by which immediate early genes mediate the effect of environment on behavior, memory, synaptic plasticity, and the risk for mental illness
The neural basis of emotion and social behavior
The role of insufficient sleep in the development of cardiometabolic disease and neurocognitive dysfunction; social/behavioral/environmental determinants of sleep; and behavioral interventions for insufficient sleep
Neuronal control of complex behavior; multimodal information processing and brain plasticity
Wireless and battery free devices that intimately integrate with biological systems by combining innovations in soft materials photonics and electronics.
Computational neuroscience, biologically-inspired engineering
Targeting RNA-protein interactions in neurogenerative diseases
Understanding the molecular and mechanistic basis of the roles of ion channels in human health and disease.
Understanding the molecular mechanisms that allow a common intracellular parasite, Toxoplasma gondii, to persist in the mammalian CNS.
Better diagnosis and protection against concussions and ischemic stroke through biomechanics and medical imaging
Functional neuroanatomy of emotion and emotion regulation in normative and clinical contexts
The opioid and chronic pain epidemics go hand in hand; my lab investigates the intersection between the physiology of chronic pain states, analgesic pharmacology, and overcoming the gatekeeper of CNS pharmacology- the blood brain barrier.
Nonlinear dynamics of neurons and networks of neurons, data assimilation & data-driven modeling, computational neuroscience.
Stem Cell Biology, Aging, and Neurodegeneration
Neurogenetic mechanisms underlying normal and abnormal vocal communication
The biology of cytotoxic T lymphocytes (CTL) in health, infection and aging
Visual perception and cognition, object recognition, figure assignment, attention, language and space, behavioral and neuropsychological studies.
Understanding the regulation of blood flow to the brain under normal and disease states; communication between neurons, astrocytes and endothelial cells that control blood flow to discrete regions of the cerebral cortex
New Methods for Organic Synthesis
Central autonomic regulation; opioids
Sex steroid modulation of neuronal morphology and gene expression in the human hypothalamus
Molecular studies of the structure and function of G-protein coupled receptors
Genetics of brain development and neuronal plasticity; genetics of mental retardation; drug discovery for developmental brain disorders
Synaptic dysfunction in neurological and psychiatric disorders related to addiction, pain and stress
Targeting transporters for blood-brain barrier protection and for delivery of neuroprotective drugs in cerebral hypoxia/ischemia
Neural basis of memory, age-related changes in memory, and how these changes relate to brain functioning
We aim to identify and characterize mechanisms and rate-limiting steps of nutrient sensing and signaling in human retina and brain using techniques in integrative omics, physiological imaging and microphysiological human systems.
Studies of molecular mechanisms of neurodegeneration (ALS, FTD, and others) using patient-derived induced pluripotent stem (iPS) cells
The genetic basis of behavioral immunity in fruit flies
Identifying and developing drugs to treat stroke, spinal cord injury and Parkinson’s disease
RNA-binding proteins involved in the pathogenesis of amyotrophic lateral sclerosis (ALS)
Development of viral vectors designed to modify the expression of voltage-gated channels in brain
Visual system neurobiology, learning and memory, brain evolution, nervous system database
Studies the molecular mechanisms of opiod receptor signal transduction, with a goal of using these mechanisms to create novel drug discovery strategies that reduce the side effects of current opiod drugs
The Sutphin Lab uses tools in systems and comparative genetics to understand the molecular basis of aging and neurodegeneration.
Neural and behavioral mechanisms of sleep deprivation-induced obesity
Understanding the neural-mediated mechanism underlying opioid tolerance and opioid-induced pain
Reinforcement learning and decision making; the neural basis of exploration and curiosity; neural and cognitive causes of "mistakes"
Cell biology of epithelial tissues; Regulation of membrane trafficking in polarized and non-polarized cells
Novel imaging of the central nervous system; smart contrast agents
Sensing and action in the natural environment.
Mitochondrial genotype and phenotype in brain aging and age-associated neurodegenerative diseases
Molecular mechanisms of aging and neurodegenerative diseases with a focus on RNA based mechanisms, stress response and metabolism.
Use mathematics and computers to study neural computation and motor control.
The laboratory studies pathogenic mechanisms of neurodegenerative diseases and molecular mechanisms essential for maintaining synaptic function and plasticity.