Neural underpinnings of internally-guided cognition, including how they develop and change across the lifespan and how they become dysfunctional in clinical populations; functional MRI; default mode network
Systems biology of aging transitions leading to risk of age-related neurodegenerative diseases, sex differences in bioenergetic aging of female and male brain, regenerative therapeutics for neurodegenerative diseases.
Neural circuits of animal behaviors, with a focus on understanding how the neural circuits regulate feeding and emotional behaviors, using optogenetics, pharmacogenetics, electrophysiology, molecular, and behavior analysis tools
Developing image-guided transcranial magnetic stimulation (TMS) approaches to improve cognitive functions and identifying TMS-derived and imaging-based biomarkers for diagnosis and prediction of therapeutic outcomes in individuals with neurodegenerative d
Cellular and rodent models to test novel pharmacological treatments for levodopa-induced dyskinesias, a major side effect of Parkinson’s disease treatment, as well as new neuroprotective gene and drug therapy approaches to Parkinson’s disease
The role of insufficient sleep in the development of cardiometabolic disease and neurocognitive dysfunction; social/behavioral/environmental determinants of sleep; and behavioral interventions for insufficient sleep
The opioid and chronic pain epidemics go hand in hand; my lab investigates the intersection between the physiology of chronic pain states, analgesic pharmacology, and overcoming the gatekeeper of CNS pharmacology- the blood brain barrier.
Understanding the regulation of blood flow to the brain under normal and disease states; communication between neurons, astrocytes and endothelial cells that control blood flow to discrete regions of the cerebral cortex
We aim to identify and characterize mechanisms and rate-limiting steps of nutrient sensing and signaling in human retina and brain using techniques in integrative omics, physiological imaging and microphysiological human systems.
Studies the molecular mechanisms of opiod receptor signal transduction, with a goal of using these mechanisms to create novel drug discovery strategies that reduce the side effects of current opiod drugs