Will McLean

Will McLean

Student Representative


McLean JW, Bhattrai A, Vitali F, Raikes AC, Wiegand JL, Brinton RD. Contributions of sex and genotype to exploratory behavior differences in an aged humanized APOE mouse model of late-onset Alzheimer's disease. Learn Mem. 2022;29(9):321-331. Published 2022 Sep 2. doi:10.1101/lm.053588.122

McLean JW, Wilson JA, Tian T, et al. Disruption of Endosomal Sorting in Schwann Cells Leads to Defective Myelination and Endosomal Abnormalities Observed in Charcot-Marie-Tooth Disease. J Neurosci. 2022;42(25):5085-5101. doi:10.1523/JNEUROSCI.2481-21.2022

Tian T, McLean JW, Wilson JA, Wilson SM. Examination of genetic and pharmacological tools to study the proteasomal deubiquitinating enzyme ubiquitin-specific protease 14 in the nervous system. J Neurochem. 2021;156(3):309-323. doi:10.1111/jnc.15180

Vaden JH, Tian T, Golf S, McLean JW, Wilson JA, Wilson SM. Chronic over-expression of ubiquitin impairs learning, reduces synaptic plasticity, and enhances GRIA receptor turnover in mice. J Neurochem. 2019;148(3):386-399. doi:10.1111/jnc.14630

Froula JM, Henderson BW, Gonzalez JC, Vaden JH, McLean JW, Wu Y, Banumurthy G, Overstreet-Wadiche L, Herskowitz JH, Volpicelli-Daley LA. α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neurons. Acta Neuropathol Commun. 2018 May 1;6(1):35. doi: 10.1186/s40478-018-0537-x


  • B.S. Neuroscience | Physics, Chemistry, Biology Minors - University of Alabama at Birmingham


Medical Pharmacology

Research Interests

Neurodegenerative Disease, Aging, Immunometabolism, Transcriptomics, Translational Science