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Jean-Paul Wiegand

Jean-Paul Wiegand's picture
First Name: 
Last Name: 
Completed Degrees: 
Neuroscience BS, MS (Brandeis U.)
Cowen lab
Rotation Labs: 
Barnes, Gothard
Distributed minor in neuroscience
Research Interests: 
I am extremely interested in the role of prediction in decision-making. Theory suggests that sequential neural firing in the hippocampus may inform place-reward associations made in the basal ganglia and ultimately, future decisions.
Research Summary: 
I am researching age-dependent and pathological changes in electrophysiological sleep patterns. It has been shown in rats that the same hippocampal place cell sequences during behavior are replayed in subsequent sleep periods, pre-played during preceding sleep periods and moreover, correlate strongly with sleep ripples, short high-frequency neural oscillations found in the hippocampus. These ripples are thought to help send memories from the hippocampus to the cortex for long-term storage and correlate strongly with sleep spindles, long low-frequency cortical oscillations. Given the relationship between memory impairments and sleep disruptions, I am exploring how electrophysiological sleep patterns change in aged rats as well as the LRRK2 transgenic mouse model for Parkinson's Disease.
In preparation: Wiegand, J. P., Bartlett, M. J., Gies, K. F., Falk T., & Cowen, S. L. (2017). Altered sleep physiology in a LRRK2 mouse model of Parkinson’s Disease.
Parent, K. L., Hill, D. F., Crown, L. M., Wiegand, J. P., Gies, K. F., Miller, M. A., & Cowen, S. L. (2017). Platform to Enable Combined Measurement of Dopamine and Neural Activity. Analytical Chemistry, 89(5), 2790-2799.
Wiegand, J. P. L., Gray, D. T., Schimanski, L. A., Lipa, P., Barnes, C. A., & Cowen, S. L. (2016). Age Is Associated with Reduced Sharp-Wave Ripple Frequency and Altered Patterns of Neuronal Variability. Journal of Neuroscience, 36(20), 5650-5660.
Houston, K.E., Bowers, A.R., Fu, X., Liu, R., Goldstein, R.B., Churchill, J., Wiegand, J.P., Soo, T., Tang, Q. & Peli, E., (2016). A Pilot Study of Perceptual-Motor Training for Peripheral Prisms. Translational vision science & technology, 5(1), pp.9-9.

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